Modelling of glucose repression signalling in yeast Saccharomyces cerevisiae
Review article, 2022

Saccharomyces cerevisiae has a sophisticated signalling system that plays a crucial role in cellular adaptation to changing environments. The SNF1 pathway regulates energy homeostasis upon glucose derepression; hence, it plays an important role in various processes, such as metabolism, cell cycle and autophagy. To unravel its behaviour, SNF1 signalling has been extensively studied. However, the pathway components are strongly interconnected and inconstant; therefore, elucidating its dynamic behaviour based on experimental data only is challenging. To tackle this complexity, systems biology approaches have been successfully employed. This review summarizes the progress, advantages and disadvantages of the available mathematical modelling frameworks covering Boolean, dynamic kinetic, single-cell models, which have been used to study processes and phenomena ranging from crosstalks to sources of cell-to-cell variability in the context of SNF1 signalling. Based on the lessons from existing models, we further discuss how to develop a consensus dynamic mechanistic model of the entire SNF1 pathway that can provide novel insights into the dynamics of nutrient signalling.

systems biology




glucose signalling


Sebastian Persson

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

University of Gothenburg

Sviatlana Shashkova

University of Gothenburg

Linnea Österberg

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

University of Gothenburg

Marija Cvijovic

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

University of Gothenburg

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 22 1

Subject Categories

Cell Biology

Cell and Molecular Biology






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