Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents
Journal article, 2022

Essential oils are important compounds for the prevention and/or treatment of various diseases in which solubility and bio-accessibility can be improved by nanoemulsion systems. Heracleum persicum oil nanoemulsion (HAE-NE) was prepared and biological properties were investigated against human breast cancer cells and normal human fibroblasts foreskin. Particle size, zeta potential and poly dispersity index were 153 nm, −47.9 mV and 0.35, respectively. (E)anethole (57.9%), terpinolene (13.8%), G-terpinene (8.1%), myrcene (6.8%), hexyl butyrate (5.2%), octyl bu-tanoate (4.5%) and octyl acetate (3.7%) was detected in nanoemulsion. Proliferation of cancer cells at IC50 = 2.32 µg/mL was significantly (p < 0.05) inhibited, and cell migration occurred at 1.5 µL/mL. The HAE-NE at 1.5, 2.5 and 3.5 µg/concentration up-regulated caspase 3 and enhanced sub-G1 peak of cell cycle with nil cytotoxic effects in the liver, kidney and jejunum of mice. Villus height, villus width, crypt depth and goblet cells in mice group fed with 10 and 20 mg/kg body weight of HAE-NE improved. Cellular redox state in the liver indicated 10 and 20 mg/kg body weight of nanoemulsion significantly up-regulated the expression of SOD, CAT and GPx genes. Heracleum persicum oil na-noemulsion could be an eco-friendly nanotherapeutic option for pharmaceutical, cosmetological and food applications.

phytochemicals

phytobiotics

therapeutics

volatile compounds

apiaceae family

plant-based nanostructures

medicinal plants

eco-friendly nanothera-peutics

Author

Shima Ghareh Bashlouei

Islamic Azad University

Ehsan Karimi

Islamic Azad University

Mohsen Zareian

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Ehsan Oskoueian

Majid Shakeri

School of Medicine

Antioxidants

2076-3921 (eISSN)

Vol. 11 5 831

Subject Categories

Cell Biology

Cell and Molecular Biology

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

DOI

10.3390/antiox11050831

PubMed

35624695

More information

Latest update

5/23/2024