Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents
Artikel i vetenskaplig tidskrift, 2022

Essential oils are important compounds for the prevention and/or treatment of various diseases in which solubility and bio-accessibility can be improved by nanoemulsion systems. Heracleum persicum oil nanoemulsion (HAE-NE) was prepared and biological properties were investigated against human breast cancer cells and normal human fibroblasts foreskin. Particle size, zeta potential and poly dispersity index were 153 nm, −47.9 mV and 0.35, respectively. (E)anethole (57.9%), terpinolene (13.8%), G-terpinene (8.1%), myrcene (6.8%), hexyl butyrate (5.2%), octyl bu-tanoate (4.5%) and octyl acetate (3.7%) was detected in nanoemulsion. Proliferation of cancer cells at IC50 = 2.32 µg/mL was significantly (p < 0.05) inhibited, and cell migration occurred at 1.5 µL/mL. The HAE-NE at 1.5, 2.5 and 3.5 µg/concentration up-regulated caspase 3 and enhanced sub-G1 peak of cell cycle with nil cytotoxic effects in the liver, kidney and jejunum of mice. Villus height, villus width, crypt depth and goblet cells in mice group fed with 10 and 20 mg/kg body weight of HAE-NE improved. Cellular redox state in the liver indicated 10 and 20 mg/kg body weight of nanoemulsion significantly up-regulated the expression of SOD, CAT and GPx genes. Heracleum persicum oil na-noemulsion could be an eco-friendly nanotherapeutic option for pharmaceutical, cosmetological and food applications.

medicinal plants



volatile compounds

eco-friendly nanothera-peutics

plant-based nanostructures

apiaceae family



Shima Ghareh Bashlouei

Islamic Azad University, Mashhad Branch

Ehsan Karimi

Islamic Azad University, Mashhad Branch

Mohsen Zareian

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Ehsan Oskoueian

Majid Shakeri

School of Medicine


2076-3921 (eISSN)

Vol. 11 5 831



Cell- och molekylärbiologi

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)



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