Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
Journal article, 2022
Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.
Author
Daniel Jons
University of Gothenburg
Henrik Zetterberg
University College London (UCL)
Sahlgrenska University Hospital
Hong Kong Center for Neurodegenerative Diseases
University of Gothenburg
Martin Biström
Umeå University
Lucia Alonso-Magdalena
Lund University
Skåne University Hospital
Martin Gunnarsson
Örebro University
M Vrethem
Linköping University
Kaj Blennow
Sahlgrenska University Hospital
University of Gothenburg
Staffan Nilsson
Chalmers, Mathematical Sciences, Applied Mathematics and Statistics
University of Gothenburg
Peter Sundström
Umeå University
Oluf Andersen
University of Gothenburg
Annals of Clinical and Translational Neurology
2328-9503 (eISSN)
Vol. 9 6 882-887Subject Categories
Clinical Laboratory Medicine
Rheumatology and Autoimmunity
Neurology
DOI
10.1002/acn3.51568
PubMed
35502756