Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
Artikel i vetenskaplig tidskrift, 2022
Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.
Författare
Daniel Jons
Göteborgs universitet
Henrik Zetterberg
University College London (UCL)
Sahlgrenska universitetssjukhuset
Hong Kong Center for Neurodegenerative Diseases
Göteborgs universitet
Martin Biström
Umeå universitet
Lucia Alonso-Magdalena
Lunds universitet
Skånes universitetssjukhus (SUS)
Martin Gunnarsson
Örebro universitet
M Vrethem
Linköpings universitet
Kaj Blennow
Sahlgrenska universitetssjukhuset
Göteborgs universitet
Staffan Nilsson
Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik
Göteborgs universitet
Peter Sundström
Umeå universitet
Oluf Andersen
Göteborgs universitet
Annals of Clinical and Translational Neurology
2328-9503 (eISSN)
Vol. 9 6 882-887Ämneskategorier
Klinisk laboratoriemedicin
Reumatologi och inflammation
Neurologi
DOI
10.1002/acn3.51568
PubMed
35502756