Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
Artikel i vetenskaplig tidskrift, 2022

Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.

Författare

Daniel Jons

Göteborgs universitet

Henrik Zetterberg

University College London (UCL)

Sahlgrenska universitetssjukhuset

Hong Kong Center for Neurodegenerative Diseases

Göteborgs universitet

Martin Biström

Umeå universitet

Lucia Alonso-Magdalena

Lunds universitet

Skånes universitetssjukhus (SUS)

Martin Gunnarsson

Örebro universitet

M Vrethem

Linköpings universitet

Kaj Blennow

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Göteborgs universitet

Peter Sundström

Umeå universitet

Oluf Andersen

Göteborgs universitet

Annals of Clinical and Translational Neurology

2328-9503 (eISSN)

Vol. 9 6 882-887

Ämneskategorier

Klinisk laboratoriemedicin

Reumatologi och inflammation

Neurologi

DOI

10.1002/acn3.51568

PubMed

35502756

Mer information

Senast uppdaterat

2024-03-07