The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study
Journal article, 2022

The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences.

Author

Anna Lindblom

University of Gothenburg

Sahlgrenska University Hospital

Camilla Kiszakiewicz

Skaraborg Hospital

Erik Kristiansson

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

University of Gothenburg

Shora Yazdanshenas

Sahlgrenska University Hospital

University of Gothenburg

Nina Kamenska

NU Hospital Group

Nahid Karami

Sahlgrenska University Hospital

University of Gothenburg

Christina Ahren

University of Gothenburg

Scientific Reports

2045-2322 (ISSN) 20452322 (eISSN)

Vol. 12 1 10048

Subject Categories

Surgery

Infectious Medicine

Urology and Nephrology

DOI

10.1038/s41598-022-14177-y

PubMed

35710924

More information

Latest update

1/9/2023 4