Multiple potential strategies for the application of nisin and derivatives
Review article, 2023

Nisin is a naturally occurring bioactive small peptide produced by Lactococcus lactis subsp. lactis and belongs to the Type A (I) lantibiotics. Due to its potent antimicrobial activity, it has been broadly employed to preserve various food materials as well as to combat a variety of microbial pathogens. The present review discusses the antimicrobial properties of nisin and different types of their derivatives employed to treat microbial pathogens with a detailed underlying mechanism of action. Several alternative strategies such as combination, conjugation, and nanoformulations have been discussed in order to address several issues such as rapid degradation, instability, and reduced activity due to the various environmental factors that arise in the applications of nisin. Furthermore, the evolutionary relationship of many nisin genes from different nisin-producing bacterial species has been investigated. A detailed description of the natural and bioengineered nisin variants, as well as the underlying action mechanisms, has also been provided. The chemistry used to apply nisin in conjugation with natural or synthetic compounds as a synergetic mode of antimicrobial action has also been thoroughly discussed. The current review will be useful in learning about recent and past research that has been performed on nisin and its derivatives as antimicrobial agents.

lactis

antimicrobial activity

nisin derivatives

nisin

nanoformulations

Lactococcus lactis subsp

pathogens

conjugation

combination

Lantibiotics

Author

Fazlurrahman Khan

Pukyong National University

Priyanka Singh

Technical University of Denmark (DTU)

Abhayraj S. Joshi

Technical University of Denmark (DTU)

Nazia Tabassum

Pukyong National University

Geum-Jae Jeong

Pukyong National University

Nilushi Indika Bamunuarachchi

Ocean University of Sri Lanka (OCUSL)

Ivan Mijakovic

Chalmers, Life Sciences, Systems and Synthetic Biology

Technical University of Denmark (DTU)

Young-Mog Kim

Pukyong National University

Critical Reviews in Microbiology

1040-841X (ISSN) 1549-7828 (eISSN)

Vol. 49 5 628-657

Subject Categories

Microbiology

Bioinformatics (Computational Biology)

Organic Chemistry

DOI

10.1080/1040841X.2022.2112650

PubMed

35997756

More information

Latest update

9/7/2023 1