2D Co metal-organic framework nanosheet as an oxidase-like nanozyme for sensitive biomolecule monitoring
Other text in scientific journal, 2023

Nanozyme-based biomolecules sensitive and quantitative detection is an attractive strategy due to their high chemical, thermal stability and reactive activity. Here, we have synthesized a significant number of two-dimensional (2D) cobalt-metal-organic framework (Co-MOF) nanosheets with oxidase (OXD)-like activity using a facile solvothermal method in one pot for biomolecule monitoring. The synthesized Co-MOF nanosheets exhibit strong stability, higher specific surface area and more active sites due to their MOF structure. Such Co-MOF nanosheets with excellent OXD-like activity show adequate analytical performance in the quantitative determination of dopamine (DA) and glutathione (GSH) with a wider dynamic sensing range and lower detection limits (DA and GSH: 0.24 and 0.067 μmol·L−1, 3σ/slope, where σ is standard deviation of the blank). This work extends the application of 2D-MOF structures in bioassays and brings new insights into the application of OXD-like nanozymes in bioassays. Graphical abstract: [Figure not available: see fulltext.]

Author

Jia Wei Guo

Jinan University

Zhongwei Yang

Jinan University

Xiu Li Liu

Jinan University

Liwei Zhang

Jinan University

Wei Bo Guo

Linyi University

Jian Zhang

Chalmers, Life Sciences, Systems and Synthetic Biology

Long Hua Ding

Jinan University

Rare Metals

1001-0521 (ISSN) 18677185 (eISSN)

Vol. 42 3 797-805

Subject Categories

Inorganic Chemistry

Analytical Chemistry

Structural Biology

DOI

10.1007/s12598-022-02179-8

More information

Latest update

7/5/2023 1