Lyotropic liquid crystal elastomers for drug delivery
Journal article, 2023
properties motivating their widespread use in biomedical applications. Development of elastomers with capacity
to deliver active therapeutic substances in the form of drugs is of particular interest to produce medical devices
with added functionality. In this work, silicone-based lyotropic liquid crystal elastomers with drug-eluting
functionality were developed using PDMS and triblock copolymer (diacrylated Pluronic F127, DA-F127).
Various ternary PDMS–DA-F127–H2O compositions were explored and evaluated. Three compositions were
found to have specific properties of interest and were further investigated for their nanostructure, mechanical
properties, water retention capacity, and morphology. The ability of the elastomers to encapsulate and release
polar and nonpolar substances was demonstrated using vancomycin and ibuprofen as model drugs. It was shown
that the materials could deliver both types of drugs with a sustained release profile for up to 6 and 5 days for
vancomycin and ibuprofen, respectively. This works demonstrates a lyotropic liquid crystal, silicone-based
elastomer with tailorable mechanical properties, water retention capacity and ability to host and release polar
and nonpolar active substances.
Drug-Delivery
Polydimethylsiloxane
Elastomers
Lyotropic Liquid Crystals
Liquid Crystal Elastomers
Triblock copolymers
Polymer Blending
Author
Annija Stepulane
Chalmers, Chemistry and Chemical Engineering, Applied Chemistry
Kajsa Ahlgren
Chalmers, Physics, Nano and Biophysics
Adrian Rodriguez Palomo
Chalmers, Physics, Materials Physics
Ananad Kumar Rajasekharan
Amferia
Martin Andersson
Chalmers, Chemistry and Chemical Engineering, Applied Chemistry
Colloids and Surfaces B: Biointerfaces
0927-7765 (ISSN) 1873-4367 (eISSN)
Vol. 226 113304Subject Categories
Polymer Chemistry
Materials Chemistry
Biomaterials Science
Infrastructure
Chalmers Materials Analysis Laboratory
Areas of Advance
Materials Science
DOI
10.1016/j.colsurfb.2023.113304
PubMed
37062225