Achieving Precision Healthcare through Nanomedicine and Enhanced Model Systems
Review article, 2024

The ability to customize medical choices according to an individual's genetic makeup and biomarker patterns marks a significant advancement toward overall improved healthcare for both individuals and society at large. By transitioning from the conventional one-size-fits-all approach to tailored treatments that can account for predispositions of different patient populations, nanomedicines can be customized to target the specific molecular underpinnings of a patient's disease, thus mitigating the risk of collateral damage. However, for these systems to reach their full potential, our understanding of how nano-based therapeutics behave within the intricate human body is necessary. Effective drug administration to the targeted organ or pathological niche is dictated by properties such as nanocarrier (NC) size, shape, and targeting abilities, where understanding how NCs change their properties when they encounter biomolecules and phenomena such as shear stress in flow remains a major challenge. This Review specifically focuses on vessel-on-a-chip technology that can provide increased understanding of NC behavior in blood and summarizes the specialized environment of the joint to showcase advanced tissue models as approaches to address translational challenges. Compared to conventional cell studies or animal models, these advanced models can integrate patient material for full customization. Combining such models with nanomedicine can contribute to making personalized medicine achievable.

Model Systems

Personalized Medicine


Drug Delivery

Cartilage Transport


Precision Medicine


Joint Drug Delivery


Elin Svensson

Chalmers, Life Sciences, Chemical Biology

Ula von Mentzer

Chalmers, Life Sciences, Chemical Biology

Alexandra Stubelius

Chalmers, Life Sciences, Chemical Biology

ACS Materials Au

2694-2461 (eISSN)

Vol. 4 2 162-173

Precision Medicine for Rheumatoid Arhtritis: Utilizing Disease Mechanisms to Achieve Self-Adjusting Nanotherapeutics

Stiftelsen Anna-Greta och Holger Crafoords fond (CR2021-0024), 2021-10-01 -- 2023-08-15.

Subject Categories

Health Care Service and Management, Health Policy and Services and Health Economy



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