Wurster fluidised-bed coating: Coarse-graining technique within CFD-DEM in conjunction with heat and mass transfer
Journal article, 2024

In this study, we use a combined CFD-Discrete Element Method to assess predictive capabilities and numerical implications of a coarse-graining technique in Wurster fluidised-bed coaters. We investigated both hydrodynamics and heat and mass transfer and conducted simulations of a full three-phase system for the original and three coarse-grained systems, analysing velocity distributions, macroscopic solid stresses, moisture content and phase temperatures. We achieved a logarithmic simulation speed-up by aggregating up to 64 original particles into each coarse grain. This was accomplished while maintaining fidelity to the original CFD-DEM system in terms of reproducing with high accuracy macroscopic granular flow properties in different regions of a coater (drying, tube and bed regions). By integrating a liquid spray and humid air, we demonstrated that the phase temperatures were accurately predicted within the coarse-grained system, with a high capability of delivering liquid spray distributions with the same uniformity and drying. We also give arguments for choosing a certain degree of coarse-graining as a compromise between a desired reduction of computational costs and a trustworthy reproduction of granular-flow physics encountered in different regions of a Wurster bed. Our findings pave the way to using CFD-DEM to industrially-scaled Wurster-bed systems, which is currently unfeasible due to prohibitive computational costs.

Three-phase system

CFD-DEM

Liquid spray modelling

Coarse-graining technique

Granular flow regime characterisation

Wurster fluidised-bed coater

Author

Philip Kjaer Jepsen

Chalmers, Mechanics and Maritime Sciences (M2)

Chalmers, Space, Earth and Environment, Energy Technology

Luis Martin De Juan

AstraZeneca AB

Astrid Boje

AstraZeneca AB

Sohan Sarangi

AstraZeneca AB

Christian von Corswant

AstraZeneca AB

Srdjan Sasic

Chalmers, Mechanics and Maritime Sciences (M2), Fluid Dynamics

Powder Technology

0032-5910 (ISSN) 1873-328X (eISSN)

Vol. 443 119901

Subject Categories

Mechanical Engineering

Physical Sciences

Chemical Engineering

DOI

10.1016/j.powtec.2024.119901

More information

Latest update

6/20/2024