PAIN IN OSTEOARTHRITIS MICE: OVARIAN HORMONES REGULATE THE RESPONSE OF A2B ADENOSINE RECEPTORS
Other conference contribution, 2024

Pain in osteoarthritis (OA) is a complex phenomenon, attributable to alteration of the subchondral bone, local inflammation of the articular tissues, and increased responsiveness of the peripheral nerve to non-noxious stimuli. The decline of ovarian hormones after menopause might be responsible for the alteration of the joint tissues, predisposing women to an increased risk of developing more painful knee OA compared to men. This could be a direct consequence of the well-known effect of estrogens on bone metabolism, on the regulation of the inflammatory mechanisms, and/or the mutual regulation of endogenous molecules. Indeed, it has been previously shown that estrogen receptors regulate adenosine synthesis and the expression of adenosine receptors. Adenosine, by activating its receptors, has an important role in the regulation of pain, inflammation, bone, and cartilage metabolism.
The purpose of this study was to evaluate the effect of the pharmacological inhibition of the A2B adenosine receptors (A2BAR) in ovariectomized and control mice in the early and late stages of OA.

Author

Sofia Wustenhagen

University of Gothenburg

Julia M. Scheffler

University of Gothenburg

Loise Råberg

Chalmers, Life Sciences, Chemical Biology

Alexandra Stubelius

Chalmers, Life Sciences, Chemical Biology

Aidan Barrett

University of Gothenburg

Fadi Askar

University of Gothenburg

Ulrika Islander

University of Gothenburg

Chalmers, Life Sciences, Systems and Synthetic Biology

Carmen Corciulo

University of Gothenburg

Osteoarthritis and Cartilage

1063-4584 (ISSN) 1522-9653 (eISSN)

Vol. 32 Supplement 1 S513-S513

OARSI World Congress on Osteoarthritis
Wien, Austria,

Subject Categories

Endocrinology and Diabetes

DOI

10.1016/j.joca.2024.02.763

More information

Latest update

8/28/2024