Time-Resolved Inspection of Ionizable Lipid-Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Early Endosomal Membrane Mimic
Journal article, 2024
endosomal escape
lipid nanoparticle fusion
lipid nanoparticle (LNP)
mRNA delivery
early endosomal membrane mimic
Author
Nima Aliakbarinodehi
Chalmers, Physics, Nano and Biophysics
Simon Niederkofler
Chalmers, Physics, Nano and Biophysics
Gustav Emilsson
AstraZeneca AB
Petteri Parkkila
Chalmers, Physics, Nano and Biophysics
Erik Olsén
Chalmers, Physics, Nano and Biophysics
Yujia Jing
AstraZeneca AB
Mattias Sjöberg
Chalmers, Physics, Nano and Biophysics
Björn Agnarsson
Chalmers, Physics, Nano and Biophysics
Lennart Lindfors
AstraZeneca AB
Fredrik Höök
Chalmers, Physics, Nano and Biophysics
ACS Nano
1936-0851 (ISSN) 1936-086X (eISSN)
Vol. 18 34 22989-23000Subject Categories
Physical Chemistry
Biochemistry and Molecular Biology
Atom and Molecular Physics and Optics
Biophysics
DOI
10.1021/acsnano.4c04519
PubMed
39133894