CELL ELECTROPERMEABILIZATION MODELING VIA MULTIPLE TRACES FORMULATION AND TIME SEMI-IMPLICIT MULTISTEP COUPLING

Journal article, 2024

We simulate the electrical response of multiple disjoint biological three-dimensional cells undergoing an electropermeabilization process. Instead of solving the boundary value problem in the unbounded volume, we reduce it to a system of boundary integrals equations___the local multiple traces formulation___coupled with nonlinear dynamics on the cell membranes. Though in time the model is highly nonlinear and poorly regular, the smooth geometry allows for boundary unknowns to be spatially approximated by spherical harmonics. This leads to spectral convergence rates in space. In time, we use a multistep semi-implicit scheme. To ensure stability, the time step needs to be bounded by the smallest characteristic time of the system. Numerical results are provided to validate our claims, and future enhancements are pointed out. © 2024 Society for Industrial and Applied Mathematics.