In Vivo Pressure Responses of the Cervical Cerebrospinal Fluid in a Porcine Model of Extension and Flexion Whiplash Exposures
Journal article, 2025

Purpose: The mechanisms of whiplash injury remain poorly understood. One theory suggests that the characteristic inertial loading of the head and neck in motor vehicle collisions can produce injurious cerebrospinal fluid (CSF) pressure transients in the cervical spine. However, these in vivo CSF pressure responses have not yet been adequately characterized. Methods: This study used a pig model to characterize the cervical CSF pressure responses to head kinematic inputs in extension (simulating low-speed rear-end collisions with no head restraint) and flexion (simulating low-speed frontal collisions). We also compared the pressure and pressure impulses at three spinal levels to determine if the pressure transient responses differ spatially. Four anesthetized pigs were instrumented with intrathecal pressure transducers placed at the C2, C5, and C7 levels. A servomotor system was programmed to actuate the head through specific trajectories to model two extension, and two flexion, whiplash exposures. Results: During the extension tests, mean peak pressure transients ranged from − 31.2 to 148.7 mmHg, whereas during the flexion tests, mean peak pressure transients ranged from − 50.8 to 126.9 mmHg. Peak individual responses ranged from − 71.1 to 244.8 mmHg across all tests. Pressure impulses reached a maximum of 6.77 mmHg·s. Peak pressure and pressure impulses were largest at the C5 and C7 levels during extension exposures and at the C2 level in flexion exposures. Conclusion: The reported pressure and pressure impulse responses could be used to determine neural tissue tolerances relevant to whiplash injury and contribute to the development and validation of computational models of whiplash.

Cervical spine

Whiplash injury

Cerebrospinal fluid

Pressure

Pig

Author

Nikoo Soltan

International Collaboration on Repair Discoveries

University of British Columbia (UBC)

Mats Svensson

Chalmers, Mechanics and Maritime Sciences (M2), Vehicle Safety

Claire F. Jones

University of Adelaide

University of Adelaide

Peter A. Cripton

International Collaboration on Repair Discoveries

University of British Columbia (UBC)

Gunter P. Siegmund

MEA Forensic Engineers & Scientists

University of British Columbia (UBC)

Annals of Biomedical Engineering

0090-6964 (ISSN) 15739686 (eISSN)

Vol. In Press

Subject Categories (SSIF 2025)

Neurosciences

Vehicle and Aerospace Engineering

DOI

10.1007/s10439-025-03695-1

PubMed

40016416

More information

Latest update

3/11/2025