Pre-existing cytotoxic capacity of CD8+and CD4+T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy
Other conference contribution, 2025
Immune checkpoint blockade (ICB) therapy has shown promising activity in Richter Transformation (RT), yet the tumor microenvironmental (TME) determinants of response and resistance to this therapy remain incompletely defined. Our previous single-cell RNA sequencing (scRNA-seq)-based analysis of splenocytes from CLL and RT mouse models identified enrichment in CD8+ effector/exhausted and CD4+ cytotoxic T cells, together with CXCL9/10+ pro-inflammatory macrophages, as a characteristic of most RT cases. The deeper characterization and the functional activities of these candidate cell populations, however, have not yet been elucidated.
Author
Johan Gustafsson
Massachusetts Institute of Technology (MIT)
University of Gothenburg
Chiara Tomasoni
Cornell University
Graydon Moorhead
Broad Inst Harvard & MIT, Canc Program
Gabriela Brunsting Hoffmann
Dana-Farber Cancer Institute
Erik Landolsi
Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering
Wesley Lu
Dana-Farber Cancer Institute
Ruitong Li
Broad Inst Harvard & MIT, Canc Program
Shuqiang Li
Dana-Farber Cancer Institute
Nicholas Haradhvala
Broad Inst Harvard & MIT, Canc Program
Connor Johnson
Broad Inst Harvard & MIT, Canc Program
Stephanie Deng
Dana-Farber Cancer Institute
Donna Neuberg
Dana-Farber Cancer Institute
Xia Bu
Dana-Farber Cancer Institute
Gordon Freeman
Dana-Farber Cancer Institute
Othman Al-Sawaf
University of Cologne
University Hospital Cologne
Barbara Eichhorst
University Hospital Cologne
University of Cologne
Erin Parry
Dana-Farber Cancer Institute
Broad Inst Harvard & MIT, Canc Program
Harvard Medical School
Gad Getz
Harvard Med Sch, Dept Pathol
Broad Inst Harvard & MIT, Canc Program
Massachusetts Gen Hosp, Krantz Family Ctr Canc Res
Massachusetts Gen Hosp, Dept Pathol
Catherine Wu
Harvard Medical School
Dana-Farber Cancer Institute
Broad Inst Harvard & MIT, Canc Program
Elisa Ten Hacken
Cornell University
Blood
0006-4971 (ISSN) 1528-0020 (eISSN)
Vol. 146 Suppl 1 243-244
67th ASH Annual meeting
Orlando, FL, USA,
Orlando, FL, USA,
Subject Categories (SSIF 2025)
Cell and Molecular Biology
Cancer and Oncology
Immunology in the Medical Area
DOI
10.1182/blood-2025-243