Pre-existing cytotoxic capacity of CD8+and CD4+T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy
Other conference contribution, 2025
Immune checkpoint blockade (ICB) therapy has shown promising activity in Richter Transformation (RT), yet the tumor microenvironmental (TME) determinants of response and resistance to this therapy remain incompletely defined. Our previous single-cell RNA sequencing (scRNA-seq)-based analysis of splenocytes from CLL and RT mouse models identified enrichment in CD8+ effector/exhausted and CD4+ cytotoxic T cells, together with CXCL9/10+ pro-inflammatory macrophages, as a characteristic of most RT cases. The deeper characterization and the functional activities of these candidate cell populations, however, have not yet been elucidated.
Author
Johan Gustafsson
University of Gothenburg
Massachusetts Institute of Technology (MIT)
Chiara Tomasoni
Weill Cornell Med, Dept Med, Div Hematol & Med Oncol
Graydon Moorhead
Broad Inst Harvard & MIT, Canc Program
Gabriela Brunsting Hoffmann
Dana Farber Canc Inst, Dept Med Oncol
Erik Landolsi
Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering
Wesley Lu
Dana Farber Canc Inst, Dept Med Oncol
Ruitong Li
Broad Inst Harvard & MIT, Canc Program
Shuqiang Li
Dana Farber Canc Inst, Dept Med Oncol
Dana Farber Canc Inst, Translat Immunogen Lab
Nicholas Haradhvala
Broad Inst Harvard & MIT, Canc Program
Connor Johnson
Broad Inst Harvard & MIT, Canc Program
Stephanie Deng
Dana Farber Canc Inst, Dept Med Oncol
Donna Neuberg
Dana Farber Canc Inst, Dept Data Sci
Xia Bu
Dana Farber Canc Inst, Dept Med Oncol
Gordon Freeman
Dana Farber Canc Inst, Dept Med Oncol
Othman Al-Sawaf
University of Cologne
University Hospital Cologne
Barbara Eichhorst
University of Cologne
University Hospital Cologne
Erin Parry
Broad Inst Harvard & MIT, Canc Program
Dana Farber Canc Inst, Dept Med Oncol
Harvard Medical School
Gad Getz
Harvard Med Sch, Dept Pathol
Massachusetts Gen Hosp, Dept Pathol
Massachusetts Gen Hosp, Krantz Family Ctr Canc Res
Broad Inst Harvard & MIT, Canc Program
Catherine Wu
Broad Inst Harvard & MIT, Canc Program
Harvard Medical School
Dana Farber Canc Inst, Dept Med Oncol
Elisa Ten Hacken
Weill Cornell Med, Dept Med, Div Hematol & Med Oncol
Blood
0006-4971 (ISSN) 1528-0020 (eISSN)
Vol. 146 Suppl 1 243-244
67th ASH Annual meeting
Orlando, FL, USA,
Orlando, FL, USA,
Subject Categories (SSIF 2025)
Cell and Molecular Biology
Cancer and Oncology
Immunology in the Medical Area
DOI
10.1182/blood-2025-243