Pre-existing cytotoxic capacity of CD8+and CD4+T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy
Övrigt konferensbidrag, 2025
Immune checkpoint blockade (ICB) therapy has shown promising activity in Richter Transformation (RT), yet the tumor microenvironmental (TME) determinants of response and resistance to this therapy remain incompletely defined. Our previous single-cell RNA sequencing (scRNA-seq)-based analysis of splenocytes from CLL and RT mouse models identified enrichment in CD8+ effector/exhausted and CD4+ cytotoxic T cells, together with CXCL9/10+ pro-inflammatory macrophages, as a characteristic of most RT cases. The deeper characterization and the functional activities of these candidate cell populations, however, have not yet been elucidated.
Författare
Johan Gustafsson
Massachusetts Institute of Technology (MIT)
Göteborgs universitet
Chiara Tomasoni
Cornell University
Graydon Moorhead
Broad Institute
Gabriela Brunsting Hoffmann
Dana-Farber Cancer Institute
Erik Landolsi
Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik
Wesley Lu
Dana-Farber Cancer Institute
Ruitong Li
Broad Institute
Shuqiang Li
Dana-Farber Cancer Institute
Nicholas Haradhvala
Broad Institute
Connor Johnson
Broad Institute
Stephanie Deng
Dana-Farber Cancer Institute
Donna Neuberg
Dana-Farber Cancer Institute
Xia Bu
Dana-Farber Cancer Institute
Gordon Freeman
Dana-Farber Cancer Institute
Othman Al-Sawaf
University Hospital Cologne
Universität zu Köln
Barbara Eichhorst
University Hospital Cologne
Universität zu Köln
Erin Parry
Dana-Farber Cancer Institute
Broad Institute
Harvard University
Gad Getz
Massachusetts General Hospital
Broad Institute
Harvard University
Catherine Wu
Harvard University
Dana-Farber Cancer Institute
Broad Institute
Elisa Ten Hacken
Cornell University
Blood
0006-4971 (ISSN) 1528-0020 (eISSN)
Vol. 146 Suppl 1 243-244
67th ASH Annual meeting
Orlando, FL, USA,
Orlando, FL, USA,
Ämneskategorier (SSIF 2025)
Cell- och molekylärbiologi
Cancer och onkologi
Immunologi inom det medicinska området
DOI
10.1182/blood-2025-243