Coupling Cell Division to Metabolic Pathways Through Transcription
Book chapter, 2025
Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.
Budding yeast
Cell cycle
Forkhead (Fkh) transcription factors
ChIP-seq
Transcriptional regulation
Gene expression
ChIP-exo
Chromatin immunoprecipitation (ChIP)
Data analysis
Metabolism
Author
Petter Holland
Chalmers, Life Sciences, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Life Sciences, Systems and Synthetic Biology
Thierry D.G.A. Mondeel
University of Amsterdam
Matteo Barberis
University of Amsterdam
Encyclopedia of Bioinformatics and Computational Biology
416-438
9780323955034 (ISBN)
Subject Categories (SSIF 2025)
Molecular Biology
Cell Biology
Medical Biotechnology
DOI
10.1016/B978-0-323-95502-7.00375-4