Coupling Cell Division to Metabolic Pathways Through Transcription
Book chapter, 2019
Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.
Transcriptional regulation
Chromatin immunoprecipitation (ChIP)
ChIP-seq
ChIP-exo
Budding yeast
Data analysis
Metabolism
Cell cycle
Forkhead (Fkh) transcription factors
Gene expression
Author
Petter Holland
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Thierry D.G.A. Mondeel
University of Amsterdam
Matteo Barberis
University of Amsterdam
Encyclopedia of Bioinformatics and Computational Biology
416-438
9780323955034 (ISBN)
Subject Categories (SSIF 2025)
Molecular Biology
Cell Biology
Medical Biotechnology
DOI
10.1016/B978-0-12-809633-8.20081-2