Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.
Journal article, 2004

The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.

Chromosomes

genetics

Middle Aged

Estrogen

Genetic Predisposition to Disease

Sweden

Parkinson Disease

genetics

epidemiology

Pair 14

genetics

Estrogen Receptor beta

Humans

Female

Aged

Odds Ratio

Age of Onset

Gene Frequency

Adult

epidemiology

Human

Male

Single Nucleotide

Chi-Square Distribution

Polymorphism

Case-Control Studies

Receptors

genetics

Author

Lars Westberg

University of Gothenburg

Anna Håkansson

University of Gothenburg

Jonas Melke

University of Gothenburg

Haydeh Niazi Shahabi

University of Gothenburg

Staffan Nilsson

University of Gothenburg

Chalmers, Department of Mathematical Statistics

S Buervenich

Karolinska Institutet

A Carmine

Karolinska Institutet

Jarl Ahlberg

University of Gothenburg

M B Grundell

Slottskogens Care Centre

B Schulhof

Slottskogens Care Centre

K Klingborg

Slottskogens Care Centre

Björn Holmberg

University of Gothenburg

O Sydow

Karolinska Institutet

L Olson

Karolinska Institutet

Bo Johnels

University of Gothenburg

Elias Eriksson

University of Gothenburg

Hans Nissbrandt

University of Gothenburg

Psychoneuroendocrinology

0306-4530 (ISSN)

Vol. 29 8 993-8

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1016/j.psyneuen.2003.08.010

PubMed

15219649

More information

Latest update

2/21/2018