Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.
Artikel i vetenskaplig tidskrift, 2004

The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.

Chromosomes

genetics

Middle Aged

Estrogen

Genetic Predisposition to Disease

Sweden

Parkinson Disease

genetics

epidemiology

Pair 14

genetics

Estrogen Receptor beta

Humans

Female

Aged

Odds Ratio

Age of Onset

Gene Frequency

Adult

epidemiology

Human

Male

Single Nucleotide

Chi-Square Distribution

Polymorphism

Case-Control Studies

Receptors

genetics

Författare

Lars Westberg

Göteborgs universitet

Anna Håkansson

Göteborgs universitet

Jonas Melke

Göteborgs universitet

Haydeh Niazi Shahabi

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Institutionen för matematisk statistik

S Buervenich

Karolinska Institutet

A Carmine

Karolinska Institutet

Jarl Ahlberg

Göteborgs universitet

M B Grundell

Slottskogens Care Centre

B Schulhof

Slottskogens Care Centre

K Klingborg

Slottskogens Care Centre

Björn Holmberg

Göteborgs universitet

O Sydow

Karolinska Institutet

L Olson

Karolinska Institutet

Bo Johnels

Göteborgs universitet

Elias Eriksson

Göteborgs universitet

Hans Nissbrandt

Göteborgs universitet

Psychoneuroendocrinology

0306-4530 (ISSN)

Vol. 29 8 993-8

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1016/j.psyneuen.2003.08.010

PubMed

15219649