Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
Journal article, 2005
The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (
Single Nucleotide
genetics
Parkinson Disease
Humans
Polymorphism
Interleukin-6
Age of Onset
genetics
Alleles
Genetic Predisposition to Disease
Estrogen Receptor beta
genetics
Linkage Disequilibrium
Genotype
genetics
Gene Frequency
Author
Anna Håkansson
University of Gothenburg
Lars Westberg
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Silvia Buervenich
Karolinska Institutet
A Carmine
Karolinska Institutet
Björn Holmberg
University of Gothenburg
O Sydow
Karolinska Institutet
L Olson
Karolinska Institutet
Bo Johnels
University of Gothenburg
Elias Eriksson
University of Gothenburg
Hans Nissbrandt
University of Gothenburg
American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics
1552-4841 (ISSN) 1552-485X (eISSN)
Vol. 133 1 88-92Subject Categories
MEDICAL AND HEALTH SCIENCES
DOI
10.1002/ajmg.b.30136
PubMed
15635591