Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
Artikel i vetenskaplig tidskrift, 2005
The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (
Single Nucleotide
genetics
Parkinson Disease
Humans
Polymorphism
Interleukin-6
Age of Onset
genetics
Alleles
Genetic Predisposition to Disease
Estrogen Receptor beta
genetics
Linkage Disequilibrium
Genotype
genetics
Gene Frequency
Författare
Anna Håkansson
Göteborgs universitet
Lars Westberg
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
Silvia Buervenich
Karolinska Institutet
A Carmine
Karolinska Institutet
Björn Holmberg
Göteborgs universitet
O Sydow
Karolinska Institutet
L Olson
Karolinska Institutet
Bo Johnels
Göteborgs universitet
Elias Eriksson
Göteborgs universitet
Hans Nissbrandt
Göteborgs universitet
American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics
1552-4841 (ISSN) 1552-485X (eISSN)
Vol. 133 1 88-92Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP
DOI
10.1002/ajmg.b.30136
PubMed
15635591