Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
Artikel i vetenskaplig tidskrift, 2005

The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (

Interleukin-6

Single Nucleotide

Polymorphism

Estrogen Receptor beta

Parkinson Disease

genetics

genetics

Genotype

Alleles

Humans

Linkage Disequilibrium

Age of Onset

Genetic Predisposition to Disease

genetics

genetics

Gene Frequency

Författare

Anna Håkansson

Göteborgs universitet

Lars Westberg

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Silvia Buervenich

Karolinska Institutet

A Carmine

Karolinska Institutet

Björn Holmberg

Göteborgs universitet

O Sydow

Karolinska Institutet

L Olson

Karolinska Institutet

Bo Johnels

Göteborgs universitet

Elias Eriksson

Göteborgs universitet

Hans Nissbrandt

Göteborgs universitet

American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics

1552-4841 (ISSN) 1552-485X (eISSN)

Vol. 133 88-92

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1002/ajmg.b.30136

PubMed

15635591