Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents
Journal article, 2007

The aqueous phase behavior of phytantriol (PT) in mixtures of monoolein (MO), distearoylphosphatidylglycerol (DSPG), propylene glycol (PG), polyethylene glycol 400 (PEG 400) and 2-methyl-2,4-pentanediol (MPD) was investigated by visual inspection, polarized light microscopy and small angle X-ray diffraction at room temperature. The phase diagrams of PT and MO in water are qualitatively very similar and PT/MO mixtures in excess water form one cubic phase of space group Pn3m irrespective of mixing ratio. The addition of the charged membrane lipid DSPG to the PT system gives rise to a considerable water swelling of the cubic phases as well as the occurrence of a cubic phase of space group Im3m. Whereas all three solvents studied give rise to a sponge (L3) phase in the MO-water system, this phase was only found when MPD was added to the PT-water system. The results are discussed with respect to the chemical differences between PT and MO.

Author

Pia Jeanette Hindrichsen

Chalmers, Chemical and Biological Engineering

Johanna Bender

Chalmers, Chemical and Biological Engineering

Johan Unga

Chalmers, Chemical and Biological Engineering

Sven Engström

Chalmers, Chemical and Biological Engineering

Journal of Colloid and Interface Science

0021-9797 (ISSN) 1095-7103 (eISSN)

Vol. 315 2 710-713

Subject Categories

Pharmaceutical Sciences

Chemical Sciences

DOI

10.1016/j.jcis.2007.07.011

More information

Created

10/7/2017