An unexpected triethylsilane-triggered rearrangement of thioaurones to thioflavonols under SPPS conditions
Journal article, 2008
Thioaurones are converted to a mixture of thiaindenes and thioflavonols when exposed to reaction conditions employed in SPPS, that is, treatment with trifluoroacetic acid in the presence of triethylsilane.
Rearrangement
Chromophores
Thioaurone
Silanes
Peptidomimetics
Reduction
Hemithioindigo
Author
Miranda Varedian
Uppsala University
Vratislav Langer
Chalmers, Chemical and Biological Engineering, Environmental Inorganic Chemistry
Jonas Bergquist
Uppsala University
Adolf Gogoll
Uppsala University
Tetrahedron Letters
0040-4039 (ISSN) 18733581 (eISSN)
Vol. 49 42 6033-6035Subject Categories
Organic Chemistry
DOI
10.1016/j.tetlet.2008.07.054