An accurate model for genetic hitchhiking
Journal article, 2008

We suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

polymorphism

signature

selective sweeps

genealogies

evolution

recombination

sampling formula

alleles

Author

Anders Eriksson

Chalmers

Pontus Fernström

University of Gothenburg

Bernhard Mehlig

University of Gothenburg

Serik Sagitov

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Genetics

0016-6731 (ISSN) 19432631 (eISSN)

Vol. 178 1 439-451

Subject Categories

Genetics

DOI

10.1534/genetics.107.076018

More information

Latest update

9/10/2018