Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
Journal article, 2009
To investigate the role of the central neuromedin U (NMU) signaling system in body weight and energy balance regulation, we examined the effects of long-term intracerebroventricular (icv) infusion of NMU in C57Bl/6 mice and in mice lacking the gene encoding NMU receptor 2. In diet-induced obese male and female C57BL/6 mice, icv infusion of NMU (8 microg x day(-1) x mouse(-1)) for 7 days decreased body weight and total energy intake compared with vehicle treatment. However, these parameters were unaffected by NMU treatment in lean male and female C57BL/6 mice fed a standard diet. In addition, female (but not male) NMUR2-null mice had increased body weight and body fat mass when fed a high-fat diet but lacked a clear body weight phenotype when fed a standard diet compared with wild-type littermates. Furthermore, female (but not male) NMUR2-null mice fed a high-fat diet were protected from central NMU-induced body weight loss compared with littermate wild-type mice. Thus, we provide the first evidence that long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
physiology
drug effects
Energy Metabolism
pharmacology
drug effects
Body Composition
Time Factors
anatomy & histology
drug effects
Body Weight
Adipose Tissue
Mice
Gene Deletion
metabolism
genetics
drug effects
Central Nervous System
Inbred C57BL
Receptors
administration & dosage
Female
Male
Knockout
genetics
Mice
Neuropeptides
genetics
physiology
Signal Transduction
drug effects
drug effects
Injections
Neurotransmitter
metabolism
Intraventricular
genetics
Energy Intake
Animals
Mice
genetics
drug effects
genetics
Author
Emil Egecioglu
University of Gothenburg
Karolina Ploj
Xiufeng Xu
Mikael Bjursell
Nicolas Salomé
University of Gothenburg
Niklas Andersson
University of Gothenburg
Claes Ohlsson
University of Gothenburg
Magdalena Taube
University of Gothenburg
Caroline Hansson
University of Gothenburg
Mohammad Bohlooly-Yeganeh
David G A Morgan
Suzanne L. Dickson
University of Gothenburg
American Journal of Physiology - Endocrinology and Metabolism
0193-1849 (ISSN) 1522-1555 (eISSN)
Vol. 297 3 E708-16Subject Categories
Physiology
DOI
10.1152/ajpendo.91022.2008
PubMed
19584200