Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
Artikel i vetenskaplig tidskrift, 2009

To investigate the role of the central neuromedin U (NMU) signaling system in body weight and energy balance regulation, we examined the effects of long-term intracerebroventricular (icv) infusion of NMU in C57Bl/6 mice and in mice lacking the gene encoding NMU receptor 2. In diet-induced obese male and female C57BL/6 mice, icv infusion of NMU (8 microg x day(-1) x mouse(-1)) for 7 days decreased body weight and total energy intake compared with vehicle treatment. However, these parameters were unaffected by NMU treatment in lean male and female C57BL/6 mice fed a standard diet. In addition, female (but not male) NMUR2-null mice had increased body weight and body fat mass when fed a high-fat diet but lacked a clear body weight phenotype when fed a standard diet compared with wild-type littermates. Furthermore, female (but not male) NMUR2-null mice fed a high-fat diet were protected from central NMU-induced body weight loss compared with littermate wild-type mice. Thus, we provide the first evidence that long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.

physiology

drug effects

Energy Metabolism

pharmacology

drug effects

Body Composition

Time Factors

anatomy & histology

drug effects

Body Weight

Adipose Tissue

Mice

Gene Deletion

metabolism

genetics

drug effects

Central Nervous System

Inbred C57BL

Receptors

administration & dosage

Female

Male

Knockout

genetics

Mice

Neuropeptides

genetics

physiology

Signal Transduction

drug effects

drug effects

Injections

Neurotransmitter

metabolism

Intraventricular

genetics

Energy Intake

Animals

Mice

genetics

drug effects

genetics

Författare

Emil Egecioglu

Göteborgs universitet

Karolina Ploj

Xiufeng Xu

Mikael Bjursell

Nicolas Salomé

Göteborgs universitet

Niklas Andersson

Göteborgs universitet

Claes Ohlsson

Göteborgs universitet

Magdalena Taube

Göteborgs universitet

Caroline Hansson

Göteborgs universitet

Mohammad Bohlooly-Yeganeh

David G A Morgan

Suzanne L. Dickson

Göteborgs universitet

American Journal of Physiology - Endocrinology and Metabolism

0193-1849 (ISSN) 1522-1555 (eISSN)

Vol. 297 E708-16

Ämneskategorier

Fysiologi

DOI

10.1152/ajpendo.91022.2008

PubMed

19584200