Iterative time-reversal for multi-frequency hyperthermia
Journal article, 2021

Time-reversal (TR) is a known wideband array beam-forming technique that has been suggested as a treatment planning alternative in deep microwave hyperthermia for cancer treatment. While the aim in classic TR is to focus the energy at a specific point within the target, no assumptions are made on secondary lobes that might arise in the healthy tissues. These secondary lobes, together with tissue heterogeneity, may result in hot-spots (HSs), which are known to limit the efficiency of the thermal dose delivery to the tumor. This paper proposes a novel wideband TR focusing method that iteratively shifts the focus away from HSs and towards cold-spots from an initial TR solution, a procedure that improves tumor coverage and reduces HSs. We verify this method on two different applicator topologies and several target volume configurations. The algorithm is deterministic and runs within seconds, enabling its use for real-time applications. At the same time, it yields results comparable to those obtained with global stochastic optimizers such as Particle Swarm.


time reversal


microwave hyperthermia


Massimiliano Zanoli

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering

Hana Dobsicek Trefna

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering

Physics in Medicine and Biology

0031-9155 (ISSN)

Vol. 66 4 045027

Subject Categories

Medical Laboratory and Measurements Technologies

Radiology, Nuclear Medicine and Medical Imaging

Medical Image Processing





More information

Latest update