Systems biology of lipid metabolism: From yeast to human
Journal article, 2009

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Metabolic model

glucose repression

reconstruction

phospholipid

genes

Lipid metabolism

proteins

models

fatty-acid

transcription factors

networks reveals

saccharomyces-cerevisiae

biosynthesis

Yeast

Systems biology

Author

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

FEBS Letters

0014-5793 (ISSN)

Vol. 583 24 3905-3913

Areas of Advance

Life Science Engineering

Subject Categories

Other Industrial Biotechnology

DOI

10.1016/j.febslet.2009.10.054

More information

Created

10/7/2017