Toward Design-based Engineering of Industrial Microbes
Journal article, 2010

Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering. © 2010 Elsevier Ltd. All rights reserved.

Author

Keith Tyo

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Kanokarn Kocharin

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Current Opinion in Microbiology

1369-5274 (ISSN)

Vol. 13 3 255-262

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

Other Industrial Biotechnology

DOI

10.1016/j.mib.2010.02.001

More information

Created

10/8/2017