Postnatal deficiency of essential fatty acids in mice results in resistance to diet-induced obesity and low plasma insulin during adulthood
Journal article, 2011

Our objective was to investigate the long-term metabolic effects of postnatal essential fatty acid deficiency (EFAD). Mouse dams were fed an EFAD diet or an isoenergetic control diet 4 days before delivery and throughout lactation. The pups were weaned to standard diet (STD) and were later subdivided into two groups: receiving high fat diet (HFD) or STD. Body composition, energy expenditure, food intake and leptin levels were analyzed in adult offspring. Blood glucose and plasma insulin concentrations were measured before and during a glucose tolerance test. EFAD offspring fed STD were leaner with lower plasma leptin and insulin concentrations compared to controls. EFAD offspring fed HFD were resistant to diet-induced obesity, had higher energy expenditure and lower levels of plasma leptin and insulin compared to controls. These results indicate that the fatty acid composition during lactation is important for body composition and glucose tolerance in the adult offspring.

Diet-induced obesity

Essential fatty acids

Body composition


Insulin-like growth factor I

Maternal diet


Energy expenditure


Vilborg Palsdottir

University of Gothenburg

Anna Wickman

University of Gothenburg

Niklas Andersson

University of Gothenburg

Rahil Hezaveh

University of Gothenburg

Bob Olsson

University of Gothenburg

Britt Gabrielsson

Chalmers, Chemical and Biological Engineering, Life Sciences, Food and Nutrition Science

Birgitta Strandvik

University of Gothenburg

Prostaglandins, Leukotrienes and Essential Fatty Acids

1532-2823 (ISSN)

Vol. 84 3-4 85-92

Subject Categories

Medical Bioscience

Biochemistry and Molecular Biology

Developmental Biology

Biomedical Laboratory Science/Technology

Other Social Sciences not elsewhere specified

Nutrition and Dietetics

Areas of Advance

Life Science Engineering (2010-2018)





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