Inclusion of magnetic dipole–dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting
Journal article, 2009

Mathematical modelling of the implant-assisted magnetic drug targeting system of Avilés, Ebner and Ritter is performed. In order to model the agglomeration of particles known to occur in this system, the magnetic dipole–dipole and hydrodynamic interactions are included. Such interactions were calculated previously by Mikkelsen et al. under low magnetic fields (~0.05 T) in microfluidic systems. Here, a higher magnetic field (0.7 T) is considered and the effect of interactions on two nanoparticles with a seed implant is calculated. The calculations were performed with the open-source software OpenFOAM. Different initial positions are considered and the system performance is assessed in terms of capture cross section. Inclusion of both interactions was seen to alter the capture cross section of the system by up to 7% in absolute terms.

Dipole–dipole interaction

Magnetic seed

Magnetic drug targeting

High-gradient magnetic separation (HGMS)

Hydrodynamic interaction

Magnetic nanoparticle


Adil Mardinoglu

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Journal of Magnetism and Magnetic Materials

0304-8853 (ISSN)

Vol. 321 23 3893-3898

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

More information