Systems biology of yeast cell death
Journal article, 2012

Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.

promotes apoptosis

fluorescent-probes

hydrogen-peroxide

caspase

activation

signaling networks

saccharomyces-cerevisiae

rat-liver mitochondria

yeast

dna

molecular-mechanisms

apoptosis systems biology

programmed cell death

fragmentation

bcl-2 protein family

Author

Ana Joyce Muñoz Arellano

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Kwanjeera Wanichthanarak

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Eugenio Meza

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Dina Petranovic Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 12 2 249-265

Subject Categories

Industrial Biotechnology

Bioinformatics and Systems Biology

Areas of Advance

Life Science Engineering

DOI

10.1111/j.1567-1364.2011.00781.x

More information

Created

10/6/2017