Aspergilli: Systems biology and industrial applications
Journal article, 2012

Aspergilli are widely used as cell factories for the production of food ingredients, enzymes and antibiotics. Traditionally, improvement of these cell factories has been done using classical methods, that is, random mutagenesis and screening; however, advances in methods for performing directed genetic modifications has enabled the use of metabolic engineering strategies. Genome sequencing of Aspergilli was originally trailing behind developments in the field of bacteria and yeasts, but with the recent availability of genome sequences for several industrially relevant Aspergilli, it has become possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology.

steady-state

proteomics

modeling approach

fluxes

carbohydrate-metabolism

niger

Industrial biotechnology

Metabolic engineering

nidulans

metabolic control analysis

genome

Aspergillus

Systems biology

citric-acid accumulation

Author

Christoph Knuf

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Biotechnology journal

1860-6768 (ISSN) 1860-7314 (eISSN)

Vol. 7 9 1147-1155

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)

European Commission (FP7), 2010-01-01 -- 2014-12-31.

Subject Categories

Biological Sciences

Areas of Advance

Energy

Life Science Engineering

DOI

10.1002/biot.201200169