Sequence-Specific Crosslinking of Electrospun, Elastin-Like Protein Preserves Bioactivity and Native-Like Mechanics.
Journal article, 2013

A nanoscale mimic of the extracellular matrix is electrospun from a highly tunable family of elastin-like proteins. A sequence-specific, two-step crosslinking procedure is developed to preserve the nanofiber morphology, elastin-like mechanics, and specific bioactivity. Rodent marrow stromal cells show sequence-specific adhesion on the matrices, which are imaged using label-free coherent anti-Stokes Raman scattering (CARS) microscopy.

Author

Patrick L Benitez

Stanford University

Jeffrey A Sweet

Stanford University

Helen Fink

Chalmers, Chemical and Biological Engineering, Molecular Imaging

Krishna P Chennazhi

Amrita Vishwa Vidyapeetham University, Kochi

Shantikumar V Nair

Amrita Vishwa Vidyapeetham University, Kochi

Annika Enejder

Chalmers, Chemical and Biological Engineering, Molecular Imaging

S. C. Heilshorn

Stanford University

Advanced healthcare materials

2192-2640 (ISSN) 2192-2659 (eISSN)

Vol. 2 1 114-118

Subject Categories

Other Medical and Health Sciences

DOI

10.1002/adhm.201200115

PubMed

23184558

More information

Latest update

3/6/2018 1