Regulatory Effects of Cu, Zn, and Ca on Fe Absorption: The Intricate Play between Nutrient Transporters
Review article, 2013
Iron is an essential nutrient for almost every living organism because it is required in a number of biological processes that serve to maintain life. In humans, recycling of senescent erythrocytes provides most of the daily requirement of iron. In addition, we need to absorb another 1-2 mg Fe from the diet each day to compensate for losses due to epithelial sloughing, perspiration, and bleeding. Iron absorption in the intestine is mainly regulated on the enterocyte level by effectors in the diet and systemic regulators accessing the enterocyte through the basal lamina. Recently, a complex meshwork of interactions between several trace metals and regulatory proteins was revealed. This review focuses on advances in our understanding of Cu, Zn, and Ca in the regulation of iron absorption. Ascorbate as an important player is also considered.
Ca
absorption
ascorbate
hepcidin expression
duodenal cytochrome-b
nramp2 expression
intestinal epithelial-cells
iron-absorption
dietary iron
caco-2 cells
Zn
Fe
transcription
fpn1
ascorbic-acid
iron
Cu
copper transporter
Author
Nathalie Scheers
Chalmers, Chemical and Biological Engineering, Life Sciences
Nutrients
2072-6643 (ISSN) 20726643 (eISSN)
Vol. 5 3 957-970Subject Categories
Biological Sciences
Nutrition and Dietetics
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.3390/nu5030957