Raloxifene and alendronate containing thin mesoporous titanium oxide films improve implant fixation to bone.
Journal article, 2013

This study tested the hypothesis that osteoporosis drug-loaded mesoporous TiO2 implant coatings can be used to improve bone-implant integration. Two osteoporosis drugs, Alendronate (ALN) and Raloxifene (RLX), were immobilized in nanoporous oxide films prepared on Ti screws and evaluated in vivo in rat tibia. The drug release kinetics were monitored in vitro by quartz crystal microbalance with dissipation and showed sustained release of both drugs. The osteogenic response after 28days of implantation was evaluated by quantitative polymerase chain reaction (qPCR), removal torque, histomorphometry and ultrastructural interface analysis. The drug-loaded implants showed significantly improved bone fixation. In the case of RLX, stronger bone-remodelling activity was observed compared with controls and ALN-loaded implants. The ultrastructural interface analysis revealed enhanced apatite formation inside the RLX coating and increased bone density outside the ALN coating. Thus, this novel combination of a thin mesoporous TiO2 carrier matrix and appropriate drugs can be used to accelerate implant fixation in trabecular bone.

Drug delivery






Necati Harmankaya

University of Gothenburg

Johan Karlsson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Anders Palmquist

University of Gothenburg

Mats Halvarsson

Chalmers, Applied Physics, Materials Microstructure

K Igawa

University of Tokyo

BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Pentti Tengvall

University of Gothenburg

Acta Biomaterialia

1742-7061 (ISSN)

Vol. 9 6 7064-73

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9/6/2018 1