Modeling yeast osmoadaptation at different levels of resolution
Review article, 2013

We review the proposed mathematical models of the response to osmotic stress in yeast. These models mainly differ in the choice of mathematical representation (e. g. Bayesian networks, ordinary differential equations, or rule-based models), the extent to which the modeling is data-driven, and predictability. The overview exemplifies how one biological system can be modeled with various modeling techniques and at different levels of resolution, and how the choice typically is based on the amount and quality of available data, prior information of the system, and the research question in focus. As a natural part of the overview, we discuss requirements, advantages, and limitations of the different modeling approaches.

yeast

glycerol

Osmotic stress

adaptation

systems

osmoregulation

saccharomyces-cerevisiae

osmotic-stress

hypotonic shock

networks

high osmolarity

mathematical modeling

signal-transduction pathway

Author

C. Kuhn

Humboldt University of Berlin

Peter Gennemark

Chalmers, Mathematical Sciences

University of Gothenburg

Uppsala University

Journal of Bioinformatics and Computational Biology

0219-7200 (ISSN)

Vol. 11 2 artikel nr 1330001-

Subject Categories

Biophysics

Bioinformatics and Systems Biology

DOI

10.1142/s0219720013300013

More information

Latest update

7/19/2021