Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy
Journal article, 2014

The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.

neuropsychology

multiple sclerosis

optic neuritis

magnetic resonance imaging

Clinically isolated syndrome

cohort

Author

Lenka Novakova

University of Gothenburg

Bengt Skoog

University of Gothenburg

Björn Runmarker

University of Gothenburg

Sven Ekholm

University of Rochester

Stefan Winblad

University of Gothenburg

Vera Lisovskaja

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Oluf Andersen

University of Gothenburg

Multiple Sclerosis

1352-4585 (ISSN) 1477-0970 (eISSN)

Vol. 20 4 496-500

Subject Categories

Clinical Medicine

DOI

10.1177/1352458513496345

More information

Created

10/7/2017