The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology
Book chapter, 2014
The African trypanosome, Ttypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.
Author
F. Achcar
University of Glasgow
A. Fadda
Heidelberg University
J. R. Haanstra
University of Groningen
Vrije Universiteit Amsterdam
Eduard Kerkhoven
Chalmers, Chemical and Biological Engineering, Life Sciences
D. H. Kim
Wellcome Trust Centre for Molecular Parasitology
A. E. Leroux
Heidelberg University
T. Papamarkou
University College London (UCL)
F. Rojas
University of Edinburgh
B.M. Bakker
University of Groningen
M. P. Barrett
Wellcome Trust Centre for Molecular Parasitology
C. Clayton
Heidelberg University
M. Girolami
University College London (UCL)
R. L. Krauth-Siegel
Heidelberg University
K. R. Matthews
University of Edinburgh
R. Breitling
University of Manchester
Advances in Microbial Physiology
0065-2911 (ISSN)
Vol. 64 115-143978-0-12-800143-1 (ISBN)
Subject Categories
Chemical Sciences
DOI
10.1016/b978-0-12-800143-1.00003-8
ISBN
978-0-12-800143-1