Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association study.
Journal article, 2014
Growth hormone deficiency (GHD) in adults is associated with decreased extracellular water volume (ECW). In response to GH replacement therapy (GHRT), ECW increases and blood pressure (BP) reduces or remains unchanged. Our primary aim was to study the association between polymorphisms in genes related to renal tubular function with ECW and BP before and 1 year after GHRT. The ECW measures using bioimpedance analysis (BIA) and bioimpedance spectroscopy (BIS) were validated against a reference method, the sodium bromide dilution method (Br(-)).
Author
Edna J L Barbosa
University of Gothenburg
Camilla A M Glad
University of Gothenburg
Anna G Nilsson
University of Gothenburg
Niklas Bosaeus
University of Gothenburg
Helena Filipsson Nyström
University of Gothenburg
Per-Arne Svensson
University of Gothenburg
Bengt-Åke Bengtsson
University of Gothenburg
Staffan Nilsson
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Ingvar Bosaeus
University of Gothenburg
Cesar Luiz Boguszewski
Universidade Federal do Parana
Gudmundur Johannsson
University of Gothenburg
PLoS ONE
1932-6203 (ISSN) 19326203 (eISSN)
Vol. 9 8 e105754- e105754Areas of Advance
Life Science Engineering (2010-2018)
Subject Categories
Other Medical and Health Sciences
DOI
10.1371/journal.pone.0105754
PubMed
25157616