Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction.
Review article, 2017
Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.
Author
Claudine Manach
INRA Centre de Clermont-Ferrand-Theix
Dragan Milenkovic
INRA Centre de Clermont-Ferrand-Theix
Tom Van de Wiele
Ghent university
Ana Rodriguez-Mateos
Heinrich Heine University Düsseldorf
Baukje De Roos
University of Aberdeen
Maria Teresa Garcia-Conesa
CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura
Rikard Landberg
Swedish University of Agricultural Sciences (SLU)
Karolinska Institutet
Eileen R Gibney
University College Dublin
Marina Heinonen
University of Helsinki
Francisco Tomás-Barberán
CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura
Christine Morand
INRA Centre de Clermont-Ferrand-Theix
Molecular nutrition & food research
1613-4133 (ISSN)
Vol. 61 6 1600557Areas of Advance
Life Science Engineering (2010-2018)
Subject Categories
Nutrition and Dietetics
DOI
10.1002/mnfr.201600557
PubMed
27687784