Systems Biology of Metabolism
Book chapter, 2017

Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.

Saccharomyces-Cerevisiae

Reconstruction proteomics

Reductive Glutamine-Metabolism

systems

In-Vivo Analysis

Genome-Scale Models

genome-scale metabolic models

Gut Microbiota

Global

metabolomics

Mitochondrial Pyruvate Carrier

metabolic engineering

Gene-Expression

Escherichia-Coli

Flux Analysis

Author

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Annual Review of Biochemistry

0066-4154 (ISSN) 1545-4509 (eISSN)

Vol. 86 245-275

Subject Categories

Bioinformatics and Systems Biology

DOI

10.1146/annurev-biochem-061516-044757

ISBN

978-0-8243-0886-5

More information

Created

10/7/2017