Serum Alkylresorcinols as Biomarkers of Dietary Gluten Exposure in Celiac disease
Journal article, 2017

Background
Therapy for celiac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established.
Aims
To evaluate the utility of alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse.
Methods
Alkylresorcinol concentrations were compared among treated CD patients (n=34), untreated CD patients (n=36), and controls (n=33). Furthermore, 7 additional CD patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, alkylresorcinol concentrations were compared in the serum of 5 mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of alkylresorcinol concentrations was also evaluated.
Results
Total alkylresorcinol concentrations were significantly lower in treated CD patients (median [IQR], 3 (2–8) nmol/L), compared to untreated CD patients (median [IQR], 32 [11–74] nmol/L; P<.0001) or healthy controls (median [IQR], 54 [23–112] nmol/L; P<.0001). Moreover, alkylresorcinol concentrations in CD patients significantly decreased after introduction of a GFD (median, 34 nmol/L at diagnosis vs. 5 nmol.L after GFD, p=0.02). In the mice, median (IQR) total alkylresorcinol concentrations in serum samples of mice fed lifelong with a gluten-free chow was 1.8 (1.6–2.3) nmol/L, which was further significantly increased to 16 (11–22) nmol/L after 8 days of feeding with the gluten free chow that had gluten added to it. (p=.008).
Conclusion
Serum alkylresorcinol concentrations could be a useful marker for dietary gluten in CD.

Gluten

Biomarkers

Author

R. S. Choung

Mayo Clinic

E. V. Marietta

Mayo Clinic

C. T. Van Dyke

Mayo Clinic

J. A. Murray

Mayo Clinic

Alastair Ross

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

FASEB Journal

0892-6638 (ISSN) 1530-6860 (eISSN)

Vol. 31 1 abstr. 315.4--

Subject Categories

Medical Laboratory and Measurements Technologies

More information

Latest update

1/18/2022