Benzo [a] phenoxazines: A new group of potent P-glycoprotein inhibitors
Journal article, 2006

The ability of fifteen novel phenoxazine derivatives (four phenoxazines and eleven benzo[a]phenoxazines) to modulate multidrug resistance (MDR) in a P-gp-overexpressing mouse T lymphoma cell line (L5178 MDR) was studied. A flow cytometric functional test, based on the differential accumulation of rhodamine 123 by sensitive and multidrug-resistant cells, was employed. Seven benzo[a]phenoxazines were observed to increase the amount of rhodamine 123 accumulated by resistant cells, i.e. to be new effective MDR modulators. The results allowed us to draw preliminary conclusions about the structural features of benzo[a]phenoxazines which are important for MDR modulation.

Author

O. Wesolowska

J. Molnar

Gunnar Westman

Chalmers, Chemical and Biological Engineering, Organic Chemistry

K. Samuelsson

M. Kawase

I. Ocsovszki

N. Motohashi

K. Michalak

In Vivo

0258-851X (ISSN)

Vol. 20 1 109-113

Subject Categories

Chemical Sciences

PubMed

16433037