Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes
Journal article, 2006

We have previously reported high immunoglobulin expression in human omental adipose tissue. The aim of this work was to investigate plasma cell density and Fc receptor (FcR) expression in human adipose tissue depots and in vitro effects of immunoglobulins on adipocyte function. Plasma cell density was higher in the visceral compared to the subcutaneous depot (10.0+/-1.56% and 5.2+/-0.98%, respectively, n=20, p<0.05). Microarray analysis revealed expression of four FcR genes in adipose tissue; FCGR2A, FCGR2B, FCER1G, and FCGRT. FCGR2A was highly expressed in adipocytes in both depots and this was verified by immunohistochemistry. Expression of IL-1beta and IL-6 was markedly reduced in adipocytes after incubation with the Fc moiety of immunoglobulin G (Fc) (p<0.01). Furthermore, Fc stimulated adipocyte lipogenesis as potently as insulin (p<0.05), but did not influence lipolysis. In conclusion, immunoglobulins produced by plasma cells in human adipose tissue could influence adipocyte metabolism and cytokine production.

Adipocytes/immunology

Male

Humans

Female

Adipose Tissue/*cytology/*immunology

Plasma Cells/*immunology

Omentum/cytology

Fc/*analysis/*genetics

Adult

Cell Count

Gene Expression

Cytokines/genetics

Oligonucleotide Array Sequence Analysis

Lipid Metabolism/immunology

Immunoglobulins/*genetics

Receptors

Author

Jenny Palming

University of Gothenburg

Britt Gabrielsson

University of Gothenburg

Eva Jennische

University of Gothenburg

Ulf Smith

University of Gothenburg

Björn Carlsson

University of Gothenburg

Lena M S Carlsson

University of Gothenburg

Malin Lönn

University of Gothenburg

Biochemical and Biophysical Research Communications

0006-291X (ISSN) 1090-2104 (eISSN)

Vol. 343 1 43-8

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1016/j.bbrc.2006.02.114

PubMed

16527253

More information

Created

10/10/2017