Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles
Journal article, 2020
We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 mu M) that are relevant to human disease.
Author
Peng-Hao Hsu
University of California at San Diego (UCSD)
Carina Arboleda
University of California at San Diego (UCSD)
Alexandra Stubelius
Chalmers, Biology and Biological Engineering, Chemical Biology
Ling-Wei Li
University of California at San Diego (UCSD)
Jason Olejniczak
University of California at San Diego (UCSD)
Adah Almutairi
University of California at San Diego (UCSD)
Biomaterials Science
2047-4830 (ISSN) 2047-4849 (eISSN)
Vol. 8 9 2394-2397Subject Categories
Physiology
Pharmacology and Toxicology
Microbiology
DOI
10.1039/c9bm02019e
PubMed
32255451