Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials
Journal article, 2020

Here we present a polycyclization of oxotriphenylhexanoates. The polycyclization is governed by electronic effects, and three major synthetic paths have been established leading to stereochemically complex tricyclic frameworks with up to five stereogenic centers. The method is compatible with an array of functional groups, allowing pharmacophoric elements to be introduced post cyclization.

Author

Martin Kamlar

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Charles University

August Runemark

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Ivana Císařová

Charles University

Henrik Sundén

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

University of Gothenburg

Organic Letters

1523-7060 (ISSN) 1523-7052 (eISSN)

Vol. 22 21 8387-8391

Subject Categories

Inorganic Chemistry

Theoretical Chemistry

Organic Chemistry

DOI

10.1021/acs.orglett.0c03020

PubMed

33079554

More information

Latest update

1/4/2021 1