Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials
Artikel i vetenskaplig tidskrift, 2020
Here we present a polycyclization of oxotriphenylhexanoates. The polycyclization is governed by electronic effects, and three major synthetic paths have been established leading to stereochemically complex tricyclic frameworks with up to five stereogenic centers. The method is compatible with an array of functional groups, allowing pharmacophoric elements to be introduced post cyclization.
Författare
Martin Kamlar
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Univerzita Karlova
August Runemark
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Ivana Císařová
Univerzita Karlova
Henrik Sundén
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Göteborgs universitet
Organic Letters
1523-7060 (ISSN) 1523-7052 (eISSN)
Vol. 22 21 8387-8391Ämneskategorier
Oorganisk kemi
Teoretisk kemi
Organisk kemi
DOI
10.1021/acs.orglett.0c03020
PubMed
33079554